Schahram Akbarian

The paper identifies a cholinergic mechanism in frontal circuits that restores attentional performance after repeated errors in a mouse model.

The paper maps R-loop landscapes in the developing human brain and shows their role in neural differentiation and gene expression programs.

This study identifies epigenetic variation linked to opioid overdose using H3K27ac profiling and machine learning, revealing splicing dysregulation and CELF5 as a key factor.

This study examines how HIV and substance use disorders affect gene expression in human ventral midbrain neurons and microglia, identifying transcriptional changes linked to disease comorbidities.

This study identifies differential chromatin architecture and risk variants in specific brain cell types associated with major depressive disorder.

This study examines somatic instability of the FGF14 GAA·TTC repeat in SCA27B, finding a cerebellar-specific expansion bias and increased instability in cerebellar regions compared to other brain areas.

The paper identifies a common flanking variant linked to increased meiotic stability at the FGF14-SCA27B repeat locus.

The paper identifies 46,802 enhancers and 164 psychiatric disorder variants with regulatory effects in the developing cortex and organoids using massively parallel reporter assays and deep learning.

The paper processes single-nuclei multi-omics data from 388 human brains to identify regulatory elements and build cell-type networks, revealing changes in aging and neuropsychiatric disorders.

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

The paper shows SATB2 influences 3D genome structure in cortical neurons, affecting gene expression and cognitive-related functions.

This paper describes a humanized mouse model using iPSC-derived microglia to study HIV-1 infection in the CNS, enabling genetic and therapeutic investigations in vivo.

This study investigates how chronic morphine exposure and withdrawal alter tRNA cytosine methylation in the medial prefrontal cortex, linking these changes to reward-seeking behavior and opioid use disorder.

The paper maps 3D chromatin structures in neuronal subtypes and shows how schizophrenia risk loci reorganize during differentiation, linking regulatory loops to gene function.

This study identifies somatic copy number variants (sCNVs) in schizophrenia cases, revealing their contribution to risk and specific NRXN1 disruptions.

The paper analyzes single nucleus transcriptomics data from opioid overdose cases and controls to show widespread glial activation and changes in gene expression related to substance use traits.

DeepMosaic detects mosaic single nucleotide variants without control samples using deep convolutional neural networks, achieving high accuracy and uncovering many variants missed by existing methods.

The paper examines HIV integration in the human brain using single nuclei transcriptomics, Hi-C, and IS-seq, finding 3D genomic reorganization and microglial activation linked to HIV infection.

The paper identifies population-level variation in enhancer expression in the human brain and links enhancer eQTL to schizophrenia heritability.

The paper identifies IL10RB as a key regulator of COVID-19 host susceptibility and severity through integrative analysis of genetic and transcriptomic data, and validates potential drug repositioning candidates.

This study shows CYLD promotes synapse pruning and weakening via Akt-mTOR-autophagy signaling, leading to behavioral and synaptic deficits in mice.

The paper evaluates brain somatic mosaicism in the adult human to identify rules governing cellular distribution during embryogenesis.

This study shows that schizophrenia risk genes have convergent and non-additive transcriptomic effects when perturbed together in human neurons, suggesting functional redundancy and complex interactions.

The paper identifies acetylated chromatin domains associated with dysfunction in schizophrenia and bipolar disorder by analyzing histone modifications in prefrontal cortex samples.

The paper identifies prenatal mutational processes in schizophrenia brains linked to transcription factor binding sites and proposes a new term 'skiagenesis' for these mutations.

The paper shows that neuron-specific chromatin domains in mice are shaped by recent retrotransposon expansions and that disrupting a silencer leads to chromatin rewiring and neuroinflammation.

This study develops a method to efficiently generate dopaminergic neurons from hiPSCs and shows they model psychiatric disease risk genes.

This study shows NSun2 deficiency in AD leads to miR-125b dysregulation and tau hyperphosphorylation, promoting neurodegeneration through epitranscriptomic mechanisms.

The paper identifies case-specific epigenetic alterations in opioid dependence using ChIP-seq and Hi-C, revealing convergent regulatory loci associated with genetic and environmental risk factors.

This study shows environmental enrichment alters chromatin structure, transcription factor binding, and 3D genome organization in mice, affecting cognitive function and gene regulation.