Solvent-Isotope Effects in Biomolecular Phase Separation and Fibrillation of Disordered Proteins and Peptides
Hanuman Singh, Zayne Yeager, Morgane Herlory, Sayanta Mahapatra, Maciej A. A. Walczak
This study shows that heavy water (D2O) systematically biases liquid-liquid phase separation and aggregation processes in disordered proteins and peptides, highlighting its role as an active experimental variable.
bioRxiv · Sep 10, 2026 · PreprintBiophysics