Maciej A. A. Walczak

Solvent-Isotope Effects in Biomolecular Phase Separation and Fibrillation of Disordered Proteins and Peptides

This study shows that heavy water (D2O) systematically biases liquid-liquid phase separation and aggregation processes in disordered proteins and peptides, highlighting its role as an active experimental variable.

N-Linked Glycosylation as a Driver of Tau Pathology and Neuronal Transmission

This study investigates how N-linked glycosylation affects Tau propagation and neuronal uptake by analyzing glycan site and structure effects on Tau-polyanion binding and seeding.

Post-Translational Modifications Control Phase Transitions of Tau

This study investigates how AD-specific post-translational modifications affect Tau self-assembly into PHFs, finding that phosphorylation generally inhibits aggregation while acetylation has variable effects.