A proteomic feasibility study connecting metabolic and synaptic pathway alterations in serum and extracellular vesicles to characterize treatment-resistant depression
Olivia B. Ramsay, Sean Anthony Burnap, Matthew F. Dobbs, Weston B. Struwe, Scott Russo, James W. Murrough, Carol V. Robinson, Tarick J. El‐Baba
This study compares serum and extracellular vesicle proteomes to identify pathway differences between treatment-resistant depression and non-treatment-resistant depression, finding distinct metabolic and synaptic pathway alterations in EVs.
bioRxiv · Aug 24, 2026 · PreprintNeuroscience