Carol V. Robinson

This study identifies YhdP as an envelope-spanning phospholipid-binding bridge that interacts with DedD to facilitate phospholipid transport in E. coli.

This study reports the cryo-EM structure of Pdr5, showing ergosterol binding and its effect on transporter activity, with implications for fungal drug resistance.

This study identifies CTL1 as a phospholipid-binding protein that deforms membranes, revealing its structural basis and potential role in phospholipid homeostasis.

This study determines the structure and function of NeRh50, a Rh-family protein in Nitrosomonas europaea, revealing lipid associations and divergent ammonium transport properties compared to canonical Amt proteins.

This study develops an integrated mass spectrometry strategy to quantify the proteoform diversity of O-glycoprotein osteopontin, revealing systematic underestimation of glycan sialylation by bottom-up methods.

This study compares serum and extracellular vesicle proteomes to identify pathway differences between treatment-resistant depression and non-treatment-resistant depression, finding distinct metabolic and synaptic pathway alterations in EVs.

This study uses mass spectrometry to show how MRAP and antagonists affect MC2R conformations and dynamics.

The paper introduces REVEAL, a mass spectrometry method to identify receptor-specific lipid binding in mammalian membrane proteins, showing agonism alters lipid occupancy and plasmalogen lipids are depleted under oxidative stress.

The paper develops a method to study endogenous protein complexes in brain tissue and finds mGluR2/3 heterodimers are abundant in specific human brain regions and associated with depression.

The paper evaluates the crosslinking efficiency of bifunctional diazirine lipid probes using STARD10 and mass spectrometry, finding that only 5% form covalent protein-lipid crosslinks.

This paper introduces modular DNA nanosensors that enable label-free, multiplexed single-molecule mass photometry to resolve protein biochemical states in complex media without washing or immobilisation.

This study shows that native electrospray ion beam deposition preserves membrane protein structure, enabling high-resolution cryo-EM analysis of complexes like AmtB.

This study reveals an atypical activation mechanism of CXCR7, identifies its role as an opioid receptor, and highlights potential for novel pain therapeutics.

The paper investigates how cardiolipin interacts with membrane proteins to stabilize them, using a model protein and simulations to identify key factors.

This study investigates how UptA interacts with undecaprenyl phosphate and how lipopeptide antibiotics inhibit this interaction.

The paper investigates how cardiac stress regulates Filamin C dimerisation through phosphorylation-modulated interactions with HSPB7, revealing evolutionary conservation of this mechanism.

This paper introduces native ES-IBD for preparing high-purity, ice-free cryo-EM samples, showing structural integrity but limitations in 2D classes and 3D EM density maps.

This study determines the structure of the GPC3-Unc5D complex and shows its role in guiding neuronal and cancer cell migration.

This study identifies proteoforms of the SARS-CoV-2 nucleocapsid protein and shows their differential interactions with RNA, cyclophilin A, and antibodies, with implications for viral replication and vaccine design.

The paper determines the structure of the T3SS export gate core using cryo-EM, revealing a helical assembly with 5:4:1 stoichiometry and identifying it as a key component of the secretion channel.