Tarick J. El‐Baba

This study compares serum and extracellular vesicle proteomes to identify pathway differences between treatment-resistant depression and non-treatment-resistant depression, finding distinct metabolic and synaptic pathway alterations in EVs.

The paper introduces REVEAL, a mass spectrometry method to identify receptor-specific lipid binding in mammalian membrane proteins, showing agonism alters lipid occupancy and plasmalogen lipids are depleted under oxidative stress.

The paper develops a method to study endogenous protein complexes in brain tissue and finds mGluR2/3 heterodimers are abundant in specific human brain regions and associated with depression.

This study identifies proteoforms of the SARS-CoV-2 nucleocapsid protein and shows their differential interactions with RNA, cyclophilin A, and antibodies, with implications for viral replication and vaccine design.