AHR activation accelerates the resolution of TGF-β1 induced fibroblast activation and promotes alveolar type 1 cell regeneration in alveolar organoids
Andrew S. Hagan, Scott Williams, Casey J. N. Mathison, Shanshan Yan, Bao Nguyen, Glenn C. Federe, Guray Kuzu, Joseph C. Siefert, Janice Hampton, Victor Chichkov, S. Whitney Barnes, Frederick J. King, Brandon L. Taylor, John R. Walker, Rui Zhao, , Rebekah S. Decker
The paper identifies DB-11-BE87 as a compound that promotes AT1 cell regeneration by reducing TGF-β1-induced fibroblast activation through AHR activation in alveolar organoids.
Communications Biology · Jul 9, 2025Peer-reviewedCell Biology