Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis
Satish Kumar Nandakumar, Sean McFarland, Laura Marlene Mateyka, Caleb A. Lareau, Jacob C. Ulirsch, Leif S. Ludwig, Gaurav Agarwal, J Engreitz, Bartlomiej P. Przychodzen, Marie Ellen McConkey, Glenn S. Cowley, John G. Doench, Jaroslaw Pawel Maciejewski, Benjamin L. Ebert, David E. Root, Vijay G. Sankaran
The paper performs a pooled loss-of-function screen in hematopoietic cells to identify genes underlying GWAS loci associated with red blood cell traits, finding 77 genes at 38 loci with biological relevance.
eLife · May 9, 2019Peer-reviewedGenomics