Jaroslaw Pawel Maciejewski

The paper detects malignant hematopoietic stem cells (HSCs) in myelodysplastic neoplasms (MDS) using low-input sequencing and shows they predict relapse after transplantation.

The paper identifies multi-hit STAG2 mutations in MDS patients, showing they are associated with worse outcomes and suggest convergent evolutionary targeting of the cohesin gene.

This study shows FLT3-ITD promotes CEBPA and p53 proteolysis via the ubiquitin-proteosome pathway, blocking differentiation and apoptosis, and suggests UPP-inhibitors as therapeutic options.

This study shows that combining Menin and XPO1 inhibitors synergistically inhibits KMT2A-r and NPM1-m AML cell growth and improves survival in xenograft models.

The paper performs a pooled loss-of-function screen in hematopoietic cells to identify genes underlying GWAS loci associated with red blood cell traits, finding 77 genes at 38 loci with biological relevance.