Structure-Led Exploration of the Metagenome Yields Novel RNA-Guided Nucleases with Broad PAM Diversity
Emmanuel LC de los Santos, Lila Rieber, Meng Wang, Seana C. Catherman, Stephen Matthew Hatfield, Tyson Bowen
The paper identifies novel RNA-guided nucleases with broad PAM diversity using structure-led metagenomic analysis, expanding genome editing capabilities.
bioRxiv · May 15, 2026 · PreprintGenomics