Stephen Matthew Hatfield

This study develops a cryogel vaccine platform that generates oxygen to overcome tumor antigen tolerance and induce durable anti-tumor immunity in prostate cancer.

The paper identifies novel RNA-guided nucleases with broad PAM diversity using structure-led metagenomic analysis, expanding genome editing capabilities.

This study shows that targeting CD73 in quasi-mesenchymal breast tumors enhances their response to anti-CTLA4 therapy through CD4+ T-cell dependence.

This study shows oxygen-carrying nanoemulsions and respiratory hyperoxia reduce tumor hypoxia, enhance T cell and NK cell infiltration, and improve cancer immunotherapy outcomes.