Mutation of NEKL-4/NEK10 and TTLL genes opposes loss of the CCPP-1 deglutamylase and prevents neuronal ciliary degeneration
Kaiden M. Power, Jyothi Shilpa Akella, Amanda Gu, Jonathon D. Walsh, Sebastian Bellotti, Margaret Morash, Winnie Zhang, Yasmin H. Ramadan, Nicole Ross, Andy Golden, Harold E. Smith, Maureen M. Barr, Robert O’Hagan
The paper identifies genes that regulate microtubule glutamylation and ciliary integrity in C. elegans, showing their role in preventing neuronal ciliary degeneration.
PLoS Genetics · Oct 16, 2020Peer-reviewedGenetics