Ngn2 induces diverse neuronal lineages from human pluripotency
Hsiu‐Chuan Lin, Zhisong He, Sebastian Ebert, Maria Schörnig, Małgorzata Santel, Anne Weigert, Wulf Hevers, Nael Nadif Kasri, Elena Taverna, J. Gray Camp, Barbara Treutlein
This study uses single-cell transcriptomics to show that Ngn2 overexpression in human iPSCs generates heterogeneous neurons, including peripheral nervous system-like populations, and that Ngn2 dosage affects neuron fate.
bioRxiv · Nov 19, 2020 · PreprintNeuroscience