Małgorzata Santel

The paper tracks mRNA mobility during human stem cell differentiation and finds that mRNA dynamics shift towards constrained patterns as cells acquire identity.

The paper uses a multiplexed single-cell transcriptomic screen to study how morphogen cues affect regional specification in human neural organoids, finding that timing, concentration, and combination of morphogens strongly influence cell type and regional composition.

The paper integrates single-cell transcriptomes and spatial transcriptomics to identify therapeutic targets in pancreatic cancer by analyzing cell states and ligand-receptor interactions in tumoroids.

The paper programs human neuron subtypes using combinatorial patterning and scRNA-seq to identify diverse neuron types and their developmental signaling networks.

The paper uses live imaging and single-cell transcriptomics to study how extracellular matrix influences brain organoid development and regionalization.

The paper creates a multi-omic atlas of human neural organoids modeling the posterior brain and identifies morphogen conditions that expand organoid models.

This paper integrates 36 single-cell transcriptomics datasets from human neural organoids into a unified atlas to assess cell type coverage and compare organoid protocols with primary brain tissue.

The paper reconstructs epigenomic trajectories in human neural organoids from pluripotency to terminal cell states using single-cell histone modification profiling.

The paper uses single-cell genomic data from human cerebral organoids to infer gene regulatory networks and assess transcription factor roles in brain development.

This study uses single-cell transcriptomics to analyze liver regeneration after portal vein embolization, identifying changes in cell states and immune interactions.

This study uses single-cell transcriptomics to show that Ngn2 overexpression in human iPSCs generates heterogeneous neurons, including peripheral nervous system-like populations, and that Ngn2 dosage affects neuron fate.

The paper uses lineage recording techniques to study brain regionalization in cerebral organoids, finding that iPSC clones accumulate in distinct brain regions and lineage restriction increases over time.

This study uses single-cell genomics to compare brain development in humans, chimpanzees, and macaques, identifying human-specific gene regulatory features.