Hsiu‐Chuan Lin

SALL1 and neural microenvironmental contextspecify identity of stem cell derived humanmicroglia-like cells

This study identifies how SALL1 and neural microenvironmental context shape the identity of stem cell-derived human microglia-like cells in 2D and 3D cultures.

Functional Cell-Type Identification in Neuronal Networks Using High-Density Microelectrode Arrays

The paper develops a classifier to identify excitatory and inhibitory neurons using HD-MEA recordings without post-hoc labeling, revealing cell-type-specific network dynamics.

CellFlow enables generative single-cell phenotype modeling with flow matching

CellFlow predicts single-cell phenotypes from complex perturbations using flow matching, demonstrating accuracy in cytokine stimulation, drug treatments, and developmental modeling.

Multi-omic human neural organoid cell atlas of the posterior brain

The paper creates a multi-omic atlas of human neural organoids modeling the posterior brain and identifies morphogen conditions that expand organoid models.

An integrated transcriptomic cell atlas of human neural organoids

This paper integrates 36 single-cell transcriptomics datasets from human neural organoids into a unified atlas to assess cell type coverage and compare organoid protocols with primary brain tissue.

Ngn2 induces diverse neuronal lineages from human pluripotency

This study uses single-cell transcriptomics to show that Ngn2 overexpression in human iPSCs generates heterogeneous neurons, including peripheral nervous system-like populations, and that Ngn2 dosage affects neuron fate.