Ganglioside GM1-enriched rafts regulate the neuronal chloride co-transporter 1 KCC2.
Cem Karakus, Aliénor Passerat de La Chapelle, Anaïs Aulas, Elizaveta Boiko, Ophélie Aubry, Marion Russeau, Anais Fougou, Alice Trahin, Seija Legas, Jérémy Aubain, Florence Molinari, Sabine Lévi, Claudio Rivera, Coralie Di Scala
This study identifies GM1 gangliosides as regulators of KCC2 membrane localization and function through lipid raft interactions, impacting chloride homeostasis and inhibitory circuit development.
bioRxiv · Mar 24, 2026 · PreprintNeuroscience