Marion Russeau

Sex-specific long-term alteration of hippocampal excitation/inhibition balance and behavior by transient caffeine exposure during synaptogenesis

This study shows that caffeine exposure during synaptogenesis causes sex-specific changes in hippocampal synaptic development and behavior, with distinct effects on anxiety, memory, and seizure susceptibility.

WNK-Dependent Phosphorylation of Gephyrin Tunes GABAA Receptors at Inhibitory Synapses and Modulates Anxiety Behavior

This study identifies a WNK-dependent phosphorylation mechanism that regulates GABAAR stability and synaptic function, leading to altered anxiety behavior in mice.

Ganglioside GM1-enriched rafts regulate the neuronal chloride co-transporter 1 KCC2.

This study identifies GM1 gangliosides as regulators of KCC2 membrane localization and function through lipid raft interactions, impacting chloride homeostasis and inhibitory circuit development.

Enhancing KCC2 function reduces interictal activity and prevents seizures in mesial temporal lobe epilepsy

This study identifies two compounds that enhance KCC2 function, reducing interictal activity and preventing seizures in mesial temporal lobe epilepsy.

Differential isoform-specific control of KCC2 function in developing cortical neurons

This study shows KCC2a regulates KCC2b function differently in developing and mature cortical neurons, acting as a developmental switch for synaptic inhibition.

NKCC1 as a signaling hub regulating KCC2 stability, chloride homeostasis, and seizure susceptibility

The paper identifies NKCC1 as a signaling hub that regulates KCC2 stability and chloride homeostasis, showing that peptides targeting NKCC1 can reduce seizure frequency in epilepsy.

Epileptic encephalopathy-related Kv2.1 mutants impair channel clustering and membrane distribution but not neuronal excitability

This study examines how mutations in Kv2.1, a potassium channel linked to epileptic encephalopathy, affect channel clustering and neuronal excitability, finding impaired clustering but no change in excitability.

Lateral diffusion of NKCC1 contributes to neuronal chloride homeostasis and is rapidly regulated by the WNK signaling pathway

The paper shows that NKCC1 lateral diffusion is regulated by the WNK1-SPAK pathway, affecting chloride homeostasis in neurons.

The fast diffusion of NKCC1 along the axon is driven by glutamatergic activity

The paper shows that NKCC1 diffusion in axons is regulated by glutamatergic activity, affecting presynaptic glutamate release and action potential firing.

5-HT1A and 5-HT2B receptor interaction and co-clustering regulates serotonergic neuron excitability

This study investigates the interaction and co-clustering of 5-HT1A and 5-HT2B receptors in serotonergic neurons and shows their functional impact on neuronal excitability.