Intratumoral microbiota-derived S1P sensitizes the combination therapy of Capecitabine and Nivolumab
Chenyi Dai, Sen-Tao Pan, Tian-Tian Qi, Huiling Shang, Ri‐hua Xie, Hao Liu, Zhenming Liu, Cui Yi-min, Yu-Hang Zhang
This study identifies how intratumoral microbiota-derived S1P enhances the efficacy of Capecitabine-Nivolumab in CRC by modulating PD-L1 expression and T cell dynamics.
bioRxiv · Jun 5, 2025 · PreprintMicrobiology