Volumetric mechanosensing of CAF in 3D hydrogels drive altered drug response in breast cancer
Somayadineshraj Devarasou, Nam Ji Sung, Seokhoon Ham, Martin Kiwanuka, Jennifer L. Young, Jennifer Hyunjong Shin
This study shows that 3D matrix stiffness affects CAF morphology and drug response in breast cancer by altering mechanotransduction and transcriptional programs.
bioRxiv · Feb 26, 2026 · PreprintBioengineering