Genome-wide analysis and polygenic prediction of clinical obesity and comparison with body mass index
Sohail Zahid, Seraj N. Grimes, April Kim, Zhiqi Yao, Allison W. Peng, Roger Scott Blumenthal, Rexford S. Ahima, Marios Arvanitis, Michael Joseph Blaha, Alexis J. Battle
The paper conducts a genome-wide analysis of clinical obesity, identifies distinct genetic loci, and shows that a clinical obesity polygenic score improves cardiovascular risk prediction compared to BMI-based scores.
medRxiv · May 22, 2026 · PreprintGenetic & Genomic Medicine