Rexford S. Ahima

The paper conducts a genome-wide analysis of clinical obesity, identifies distinct genetic loci, and shows that a clinical obesity polygenic score improves cardiovascular risk prediction compared to BMI-based scores.

This study shows that IPMK deficiency in skeletal muscle leads to metabolic disorders including weight gain, glucose intolerance, and reduced exercise capacity.

This study shows that excess free fatty acids (FFA) reduce IPMK expression and Akt phosphorylation in mouse hepatocytes, contributing to insulin resistance and NAFLD.

This study shows that IPMK regulates hepatic insulin signaling and gluconeogenesis, with loss of IPMK leading to increased glucose production and insulin resistance in mice.

This study shows that deleting the hepatic androgen receptor in female mice prevents androgen-induced insulin resistance and glucose intolerance.

This study shows that reducing Perilipin2 in beta cells impairs insulin secretion and mitochondrial function under nutritional stress.

This study shows that O-GlcNAcylation and oxidative stress via CaMKII contribute to atrial fibrillation in type 1 and type 2 diabetes through distinct mechanisms.