April Kim

Genome-wide analysis and polygenic prediction of clinical obesity and comparison with body mass index

The paper conducts a genome-wide analysis of clinical obesity, identifies distinct genetic loci, and shows that a clinical obesity polygenic score improves cardiovascular risk prediction compared to BMI-based scores.

Polygenic prediction of phenotypes with a neural empirical Bayes approach

This paper introduces PRSFNN, a neural empirical Bayesian method for polygenic prediction that outperforms existing methods on 17 of 18 traits in the UK Biobank.

Using brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia

The paper uses brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia and identifies enriched networks and genes associated with the disease.

Genoppi: an open-source software for robust and standardized integration of proteomic and genetic data

Genoppi integrates proteomic and genetic data to identify cell-type-specific interactions and their role in disease.

Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

The paper introduces a Bayesian framework to prioritize risk genes for complex diseases by integrating gene-set information with variant counts, identifying novel epilepsy risk genes and linking them to immune pathways and drug targets.

GeNets: A unified web platform for network-based analyses of genomic data

GeNets provides a platform to compare genomic networks using machine learning and allows analysis of genetic and RNA sequencing data.

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders

The paper uses Bayesian modeling to analyze rare exonic variants in schizophrenia and neurodevelopmental disorders, identifying 1,551 risk genes for schizophrenia and 98 new risk genes for developmental disorders.

Detecting cancer vulnerabilities through gene networks under purifying selection in 4,700 cancer genomes

The paper identifies 685 putative cancer-related genes by analyzing mutation depletion in protein interaction networks across 4,700 cancer genomes.

Genoppi: a web application for interactive integration of experimental proteomics results with genetic datasets

Genoppi integrates proteomics and genetic datasets to identify biological relationships, offering a user-friendly web application for this purpose.