Author

Serena Kesha

Massachusetts Institute of Technology

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Biochemistry· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:long-read sequencing· 1 Assay:protein structure· 1

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Roberto J. Vazquez NuneziD· 1 shared Seychelle M. VosiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiochemistry

Roberto J. Vazquez NunezORCID

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Recent·Most cited

A sequence-encoded promoter proximal super pause stabilizes an offline RNA polymerase II state

Roberto J. Vazquez Nunez, Serena Kesha, Seychelle M. Vos

A reconstituted, direct-RNA-sequencing transcription assay on 1,000 human promoter-proximal sequences identified a TFIIS-insensitive consensus super pause, whose cryo-EM structure shows a one-nucleotide sidetracked polymerase state.

bioRxiv · Jul 24, 2026 · PreprintBiochemistry✦ In-depth digest