Author

Roberto J. Vazquez Nunez

Massachusetts Institute of TechnologyORCID 0000-0003-3375-1671Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Organism:human· 1 Assay:long-read sequencing· 1 Assay:protein structure· 1

Frequent Co-Authors

Seychelle M. VosiD· 2 shared Andreas MayeriD· 1 shared Annkatrin BressiniD· 1 shared Serena Kesha· 1 shared Zhihao ShaoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersBiochemistry

Seychelle M. VosORCID

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2 papers

Recent·Most cited

A sequence-encoded promoter proximal super pause stabilizes an offline RNA polymerase II state

Roberto J. Vazquez Nunez, Serena Kesha, Seychelle M. Vos

A reconstituted, direct-RNA-sequencing transcription assay on 1,000 human promoter-proximal sequences identified a TFIIS-insensitive consensus super pause, whose cryo-EM structure shows a one-nucleotide sidetracked polymerase state.

bioRxiv · Jul 24, 2026 · PreprintBiochemistry✦ In-depth digest

ELOF1 is a core component of the promoter-proximal paused RNA polymerase II complex

Roberto J. Vazquez Nunez, Annkatrin Bressin, Zhihao Shao, Andreas Mayer, Seychelle M. Vos

This study identifies ELOF1 as a critical factor enhancing promoter-proximal RNA polymerase II pausing, showing its role in counteracting TFIIF effects.

bioRxiv · May 28, 2026 · PreprintMolecular Biology