Prefrontal parvalbumin neurons as a target for enhancing cognition in non-pathological and 22q11.2 microdeletion syndrome mice
Tyler D. Dexter, Daniel D. Palmer, Ashley L. Schormans, Shahnaza Hamidullah, Meira M. F. Machado, Brian Leonard Allman, Timothy J. Bussey, Lisa M. Saksida
This study investigates the role of prefrontal parvalbumin neurons in attention and cognition, showing reduced activity in attention-deficient mice and 22q11.2 mutants, and demonstrates that gamma stimulation can improve task performance.
Molecular Psychiatry · Dec 14, 2025Peer-reviewedNeuroscience