Lisa M. Saksida

The paper investigates how different striatal dopaminergic pathways contribute to visuomotor conditional learning, finding that only nigrostriatal DA is necessary for learning.

This study identifies myelin maturation failure and oligodendrocyte precursor loss as underlying causes of default mode network disruption in an Alzheimer's disease mouse model.

This study tracks how striatal α-synuclein seeding affects brain networks and cognitive flexibility in marmosets, showing multi-scale reorganization and impaired cognitive flexibility.

This study investigates the role of prefrontal parvalbumin neurons in attention and cognition, showing reduced activity in attention-deficient mice and 22q11.2 mutants, and demonstrates that gamma stimulation can improve task performance.

This paper develops a touchscreen-based Go/No Go task to assess cognitive judgement bias in mice, showing that bupropion induces optimism while tetrabenazine induces pessimism.

The paper shows that cholinergic synaptic plasticity, specifically VAChT responses to tau, correlates with cognitive resilience in presymptomatic AD.

This study identifies neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model, showing early cognitive deficits and brain atrophy linked to prion-like spread of misfolded alpha-synuclein.

The paper shows that activity in perirhinal and entorhinal cortex best predicts perceived visual similarities between category exemplars compared to other ventral visual stream regions.

The paper develops an optimized GRABACh sensor to measure in vivo cholinergic activity in Drosophila and mice, revealing compartmental ACh signals and single-trial dynamics.

The paper shows that restoring C6S levels in aged brains improves memory by reversing perineuronal net inhibition.

The paper shows that basal forebrain and brainstem cholinergic neurons differentially affect amygdala circuits and behavior through distinct mechanisms.