scFv intrabody targeting wildtype TDP-43 presents protective effects in a cellular model of TDP-43 proteinopathy
Yara Al Ojaimi, Rudolf C. Hergesheimer, Anna A. Chami, Hugo Alarcan, Johanna Augros, Audrey Dangoumau, Shanez Haouari, Jérôme Bourgeais, Antoine Lefèvre, Samira Osman, Patrick Emond, Patrick Vourc’h, Christian Robert Andres, Philippe Corcia, Olivier Hérault, , Hélène Blasco
The paper identifies two scFv intrabodies that bind to wildtype TDP-43 and show protective effects in a cellular model of TDP-43 proteinopathy.
PLoS ONE · Aug 4, 2025Peer-reviewedNeuroscience