Endogenous inflammatory mediators produced by injury activate TRPV1 and TRPA1 nociceptors to induce sexually dimorphic cold pain that is dependent on TRPM8 and GFRalpha3
Chenyu Yang, Shanni Yamaki, Tyler Jung, Brian Kim, Ryan Huyhn, David D. McKemy
The paper shows that inflammatory mediators activate TRPV1 and TRPA1 nociceptors, leading to cold pain in mice that depends on TRPM8 and GFRalpha3, with sex-specific effects.
Journal of Neuroscience · Mar 10, 2023Peer-reviewedNeuroscience