AptaDiff: de novo design and optimization of aptamers based on diffusion models
Zhen Wang, Ziqi Liu, Wei Zhang, Yanjun Li, Yizhen Feng, Shaokang Lv, Han Diao, Zhaofeng Luo, Pengju Yan, Min He, Xiaolin Li
AptaDiff generates and optimizes aptamers using diffusion models, outperforming existing methods and experimental candidates in binding affinity.
Briefings in Bioinformatics · Sep 23, 2024Peer-reviewedBioinformatics