Xiaolin Li

EukaUTR: a foundation model unifying functional modelling and design of eukaryotic 3' UTRs

EukaUTR is a foundation model for eukaryotic 3' UTRs that predicts function and generates new sequences with regulatory properties.

CodonMamba: a foundation model for programmable mRNA coding sequence design

CodonMamba is a foundation model for mRNA coding sequence design that achieves state-of-the-art performance and enables programmable codon optimization through inference-time steering.

AptaDiff: de novo design and optimization of aptamers based on diffusion models

AptaDiff generates and optimizes aptamers using diffusion models, outperforming existing methods and experimental candidates in binding affinity.

DyScore: A Boosting Scoring Method with Dynamic Properties for Identifying True Binders and Non-binders in Structure-based Drug Discovery

DyScore improves protein-ligand binding prediction by incorporating dynamic features into a boosting model, achieving better performance than existing methods.