The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity
Shaorong Fan, Wenju Sun, Ligang Fan, Nan Wu, Wei Sun, Haiqian Ma, Siyuan Chen, Zitong Li, Yu Li, Jilin Zhang, Jian Yan
This study identifies conserved RNA-binding motifs in coronavirus nucleocapsid proteins that enable broad-spectrum antiviral drug development.
Computational and Structural Biotechnology Journal · Jan 1, 2022Peer-reviewedMolecular Biology