UCA1 lncRNA represses γ-globin expression by sequestering miR-148b, a key post-transcriptional regulator of BCL11A
Motiur Rahaman, Shatarupa Bhattacharya, Mandrita Mukherjee, Chiranjib Bhowmick, Praphulla Chandra Shukla, Tuphan Kanti Dolai, Nishant Chakravorty
The paper identifies UCA1 lncRNA as a ceRNA that sequesters miR-148b, increasing BCL11A expression and reducing γ-globin levels in adult erythroid cells.
bioRxiv · Aug 29, 2025 · PreprintGenetics