5'-S-(3-aminophenyl)-5'-thioadenosine, a novel chemoprotective agent for reducing toxic side effects of fluorouracil in treatment of MTAP-deficient cancers
Si Zhang, Hui Xue, Nelson K.Y. Wong, Thomas A. Doerksen, Fuqiang Ban, Shawn A. Anderson, Stanislav V. Volik, Yen‐Yi Lin, Zhongye Dai, Ivica Bratanovic, Hongwei Cheng, Colin C. Collins, Artem R Cherkasov, Jeremy E. Wulff, Yuzhuo Z. Wang
This paper identifies m-APTA, an MTA analogue that reduces NBA toxicity without hypothermia, improving safety for MTAP-deficient cancer treatment.
Molecular Cancer Therapeutics · Mar 8, 2025Peer-reviewedCancer Biology