MYRF drives heterochronic miRNAs and LIN-42, and amplifies oscillatory programs for stage transitions
Zhao Wang, Shiqian Shen, Xiaoting Feng, Di Chen, Qian Bian, Yingchuan Billy Qi
This study identifies MYRF as a master temporal regulator in C. elegans larval development, showing it drives oscillatory gene networks and stage transitions through microRNA activation and feedback loops.
bioRxiv · Jan 29, 2026 · PreprintDevelopmental Biology