Novel mouse model of cerebral microbleeds created by Crispr/Cas9-mediated Col4a1 deletion in adult brain microvessels
Hyunmi Kim, Yeojin Seo, Heekyung Kho, Shivani Shailendrakumar Singh, Jina Lee, Hohyeon Lee, Ji-Won Hwang, Tae‐Ryong Riew, Seungyon Koh, Jun Young Choi, Hyun Woong Roh, Sang Joon Son, Gi Tae Kim, Sung Kweon Cho, Hyun‐Seok Jin, , Byung Gon Kim
This study creates a novel mouse model of cerebral microbleeds by deleting Col4a1 in adult brain microvessels, showing progressive CMB burden and cognitive decline.
bioRxiv · Jun 22, 2025 · PreprintNeuroscience