Antibody-Based Targeting of the SPP1-CD44 Axis in Pediatric High-Grade Glioma through Single-Cell and Structural Bioinformatics
This study identifies the SPP1-CD44 axis as an immunosuppressive pathway in pediatric high-grade glioma and develops an antibody to disrupt it using single-cell and structural bioinformatics.
bioRxiv · May 1, 2025 · PreprintBioinformatics