Author

Shiyuan Chen

University of California, RiversidePrimary ORCID profile (0000-0001-9805-2906 · 8 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Shiyuan CheniD8 papers · Stowers Institute for Medical Research

Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:large language model· 1 Assay:long-read sequencing· 1 Research Focus:protein design· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Joy S. XiangiD· 1 shared Lili WangiD· 1 shared Neil R. FernandesiD· 1 shared Wei Vivian LiiD· 1 shared Zhenyu JiaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperBioengineering

Joy S. XiangORCID

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1 paper

Recent·Most cited

RNASeek: A Cross-Phyla Generative Foundation Model for Multipurpose RNA Modeling and Reinforcement Learning-Based Design

Shiyuan Chen, Neil R. Fernandes, Wei Vivian Li, Lili Wang, Zhenyu Jia, Joy S. Xiang

RNASeek is a generative foundation model for RNA sequence design and functional prediction, using reinforcement learning to optimize RNA properties like stability and cleavage activity.

bioRxiv · Sep 28, 2026 · PreprintBioengineering