Structural and functional insights into multiple BAM-bound conformations of BepA enabling substrate triage at the outer membrane
Ryoji Miyazaki, Mai Kimoto, Hidetaka Kohga, Takeru Nishi, Katsuhiro Sawasato, Yutaro S. Takahashi, Sho Asai, Yasushi Daimon, Takehiro Suzuki, Fina Amreta Laksmi, Yudhi Nugraha, Naoshi Dohmae, Hideki Shigematsu, Shin‐ichiro Narita, Yoshinori Akiyama, Tomoya Tsukazaki
This study reports cryo-EM structures of BAM-BepA complexes and identifies loop conformations that regulate BepA's dual function in substrate triage.
bioRxiv · Aug 5, 2026 · PreprintMolecular Biology