Hideki Shigematsu

The paper determines the cryo-EM structure of the MurJ-SglPP7 complex, revealing how SglPP7 inhibits MurJ and suggesting convergent evolution among phage lysis proteins.

This study evolves an artificial nucleocapsid from a circularly permuted bacterial protein cage, revealing heterogeneous cage architectures with distinct subunit arrangements and conformations.

This study determines cryo-EM structures of the E. coli BAM complex in different environments, identifying new conformational states involved in lateral-gate closure during OMP insertion.

This study reports cryo-EM structures of BAM-BepA complexes and identifies loop conformations that regulate BepA's dual function in substrate triage.

This study identifies CAMSAP2 condensates as a γ-TuRC-independent mechanism for non-centrosomal microtubule nucleation through phase separation and tubulin organization.

The paper compares monomer and dimer structures of NmqNOR to show how dimerization enhances enzymatic activity by stabilizing the active site conformation.

This paper reports high-resolution structures of kinesin-14 motor proteins during different mechanochemical states, revealing structural transitions that drive force generation and the power stroke.

This study shows human spastin functions as an ATPase-independent microtubule nucleator by forming ring-stack structures, redefining its role in microtubule dynamics and HSP pathology.

This study reveals dynamic interactions between SurA and BAM components in OMP assembly using cryo-EM structures.

The paper reveals how phage lysis protein LysM blocks MurJ conformational changes by acting as a wedge, providing a structural basis for designing antimicrobial agents targeting MurJ.

The paper reports the crystal and cryo-EM structures of a xylose transporter in the PTS system, revealing its mechanism for recognizing and transporting D-xylose.

This study identifies amino acid substitutions in KIF5A from giraffes and pythons that enhance axonal transport speed, revealing convergent evolutionary adaptations for long-distance transport.

This study uses cryo-EM to determine high-resolution structures of type I and IV pili from enterotoxigenic Escherichia coli, revealing subunit interactions and hydrated water molecules.