Reducing encapsidated impurity DNA derived from plasmid backbone by modifying the p5 terminal resolution site in rAAV vector production
Yuya Nishimura, Shoko Hataya, Shunsuke Saito, Naoki Makita
This study modifies the p5 terminal resolution site in AAV vectors to reduce encapsidated plasmid backbone DNA, improving vector safety and yield.
bioRxiv · May 8, 2026 · PreprintBioengineering