Proof-of-Concept in a Murine Model of Treatment of Thrombotic Thrombocytopenic Purpura Using Engineered Red Blood Cells
Karl Roberts, Shouping Zhang, Batbayar Khulan, Zi Yan, Joshua Muia, Joseph Justin Mulvey, Emmanuel N. Olivier, James M. Pullman, Spero R. Cataland, Eric E. Bouhassira
This paper demonstrates that engineered red blood cells expressing ADAMTS13 can treat TTP in mice by cleaving vWF under physiological conditions.
bioRxiv · Jun 12, 2025 · PreprintCell Biology