Addition of chemotherapy to radiotherapy promotes progenitor-exhausted CD8+ T-cell clonal dominance in head and neck cancer
Charleen Chan Wah Hak, Anton Patrikeev, Antonio Rullan, Emmanuel Christian Patin, Victoria Roulstone, Lisa C. Hubbard, Matthew Guelbert, Elizabeth S. Appleton, Shane Foo, Isaac Dean, Amy Burley, Joan Kyula, Holly Baldock, Jen Y. Lee, Pablo Nenclares, , Alan A. Melcher
This study shows that chemoradiotherapy (CRT) in head and neck cancer promotes clonal dominance of progenitor-exhausted CD8+ T-cells compared to radiotherapy alone.
bioRxiv · Mar 18, 2026 · PreprintCancer Biology