Author

Joan Kyula

Institute of Cancer ResearchORCID 0000-0002-9299-0544Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alan A. MelcheriD· 3 shared Anton PatrikeeviD· 3 shared Emmanuel Christian PatiniD· 3 shared Kevin Joseph HarringtoniD· 3 shared Malin PederseniD· 3 shared Masahiro OnoiD· 3 shared Shane FooiD· 3 shared Victoria RoulstoneiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Alan A. MelcherORCID

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3 papers

Recent·Most cited

Intratumoural oncolytic HSV-1 reshapes the local and systemic immune landscape through CD8+ T cell reprogramming

Elizabeth S. Appleton, Anton Patrikeev, Victoria Roulstone, Mikel Portillo, Jehanne Hassan, Shane Foo, Lisa Hubbard, Joan Kyula, Isaac Dean, Ernesto López, Charleen Chan Wah Hak, Malin Pedersen, Antonio Rullan, Chanidapa Adele Tye, Mark Allen, , Alan A. Melcher

This paper shows that intratumoural oncolytic HSV-1 reprograms systemic immunity by inducing specific CD8 T cell populations that correlate with clinical response to immunotherapy.

bioRxiv · May 29, 2026 · PreprintCancer Biology

Addition of chemotherapy to radiotherapy promotes progenitor-exhausted CD8+ T-cell clonal dominance in head and neck cancer

Charleen Chan Wah Hak, Anton Patrikeev, Antonio Rullan, Emmanuel Christian Patin, Victoria Roulstone, Lisa C. Hubbard, Matthew Guelbert, Elizabeth S. Appleton, Shane Foo, Isaac Dean, Amy Burley, Joan Kyula, Holly Baldock, Jen Y. Lee, Pablo Nenclares, , Alan A. Melcher

This study shows that chemoradiotherapy (CRT) in head and neck cancer promotes clonal dominance of progenitor-exhausted CD8+ T-cells compared to radiotherapy alone.

bioRxiv · Mar 18, 2026 · PreprintCancer Biology

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T cell receptor signalling.

Edward John Lloyd Armstrong, Matthew Kin-Liang Chiu, Shane Foo, Lizzie Appleton, Pablo Nenclares, Anton Patrikeev, Nitya Mohan, Martin Mclaughlin, Galabina Bozhanova, Julia Hoebart, Victoria Roulstone, Emmanuel Christian Patin, Malin Pedersen, Joan Kyula, Masahiro Ono, , Victoria A. Jennings

This study shows that combining oncolytic Maraba virus with PD-1 blockade overcomes resistance in advanced melanoma with a cold tumor microenvironment.

Journal for ImmunoTherapy of Cancer · Jul 1, 2024Peer-reviewedCancer Biology