Interpretable Deep Learning Reveals Biologically Relevant Spatial Gene Expression Patterns in Lung Tumors and their Microenvironment
Vibha R. Rao, Adrienne A. Workman, Liang Lu, Xiaoying Liu, Shrey S. Sukhadia
XpressO-Lung predicts spatial gene expression patterns in LUAD tumors and their microenvironment from H&E images, achieving high accuracy and aligning with known biological interactions.
bioRxiv · Sep 17, 2025 · PreprintPathology