Mitotic bookmarking by Prox1 preserves mammalian neuronal lineage identity memory via promoting timely H3K27me3 restoration
Chouin Wong, Jiayi Liu, Haoran Yang, Haotian Li, Xiaoqi Luo, Tingyi Li, Zili Chen, Jingyi Chu, Yuying Shen, Shuai Long, Yong Zhang, Yan Song
This paper shows that Prox1 acts as a mitotic bookmark in mouse hippocampal neural stem cells to preserve neuronal lineage identity by promoting H3K27me3 restoration.
bioRxiv · Feb 26, 2026 · PreprintDevelopmental Biology