Yong Zhang

Intrinsic immune receptor triggering mechanism informs rational chimeric receptor design

The paper identifies CD3ε as a primary trigger subunit in TCR activation through phase separation with Lck, leading to the design of TRIG molecules that activate T and NK cells via endogenous receptor signaling.

The ammonia-senescence ratchet drives an adaptation-senescence-ammonioptosis transition in liver cancer

This study identifies an ammonia-senescence ratchet mechanism that drives tumor cells from metabolic adaptation to senescence and ultimately to ammonioptosis.

Extracellular vesicle-mediated suppression of macrophage STING signaling promotes immune dysfunction in dedifferentiated liposarcoma

This study shows that extracellular vesicles from dedifferentiated liposarcoma suppress macrophage STING signaling, leading to immune dysfunction and poor response to immunotherapy.

Immunometabolic Remodeling of Perivascular Adipose Tissue in Murine Lupus: Implications for Lupus Vasculopathy

This study identifies molecular changes in perivascular adipose tissue in lupus mice, showing mitochondrial dysfunction, immune activation, and impaired adipogenic capacity.

Mitotic bookmarking by Prox1 preserves mammalian neuronal lineage identity memory via promoting timely H3K27me3 restoration

This paper shows that Prox1 acts as a mitotic bookmark in mouse hippocampal neural stem cells to preserve neuronal lineage identity by promoting H3K27me3 restoration.

Mechanical force regulates the inhibitory function of PD-1

This study shows that PD-1 ligand interactions are force-dependent and soluble PD-L1 can block PD-1, suggesting new approaches for cancer immunotherapy.

CD28 Co-stimulation Is Organized by Signaling Condensates and Counteracted by PD-1

This study shows CD28 co-stimulation forms signaling condensates with Lck, which PD-1 modulates by binding and disrupting these structures, leading to engineered CAR T cells with improved antitumor activity.

BiOmics: A Foundational Agent for Grounded and Autonomous Multi-omics Interpretation

BiOmics introduces an AI agent that improves multi-omics interpretation by combining reasoning and embedding spaces, outperforming existing methods in variant discovery, cell annotation, and drug repurposing.

Principles of nutrition-dependent root-microbiome engineering for regulating crop yield via live microbial inoculants

This study investigates how soil nutrient status affects bioinoculant effectiveness in wheat production systems, revealing the impact of soil organic carbon on microbial community stability and crop yield.

BioLLM: A Standardized Framework for Integrating and Benchmarking Single-Cell Foundation Models

BioLLM integrates and benchmarks single-cell foundation models, revealing scGPTs' robust performance and highlighting limitations of scBERT in gene-level tasks.

Development and validation of a six-RNA binding proteins prognostic signature and candidate drugs for prostate cancer

The paper identifies a six-RNA binding protein prognostic signature and three candidate drugs for prostate cancer using TCGA data and Connectivity Map.

SIRT3-dependent mitochondrial oxidative stress in sodium fluoride-induced hepatotoxicity and salvage by melatonin

This study shows melatonin reduces fluoride-induced oxidative stress in HepG2 cells and mice by enhancing SIRT3 activity and PGC-1/ERR-mediated SIRT3 expression.

Dual functions of Intraflagellar Transport Protein IFT20 in spermiogenesis: formation of sperm flagella and removal of cytoplasm by autophagy

This study shows that IFT20 is crucial for sperm flagella formation and cytoplasm removal via autophagy in mice.