Dissecting endothelial to haematopoietic stem cell transition by single-cell transcriptomic and functional analyses
Siyuan Hou, Zongcheng Li, Xiaona Zheng, Yun Gao, Ji Dong, Yanli Ni, Xiaobo Wang, Yunqiao Li, Xiaochen Ding, Zhilin Chang, Shuaili Li, Yuqiong Hu, Xiaoying Fan, Yu Hou, Lu Wen, , Yu Lan
The paper identifies HSC-primed hemogenic endothelial cells in mouse embryos using single-cell transcriptomics and functional validation, revealing their developmental trajectory and bi-potential.
Cell Research · Mar 20, 2020Peer-reviewedDevelopmental Biology