Fuchou Tang

The paper identifies lncRNAs in human germ cells and shows LNC1845 regulates LHX8 through histone modifications during gonadal development.

The paper introduces SCORE, a network-based method that improves single-cell cellular state inference by incorporating molecular network features, identifying novel cell clusters and biological insights in human ileal scRNA-seq data.

This paper introduces COSLIR, a method to directly reconstruct gene regulatory networks from time-stamped single-cell data without pseudo-time inference, showing good performance on real datasets.

The paper introduces scTHI, a method to identify ligand-receptor interactions in glioma using single-cell RNA sequencing data from six human datasets.

This study uses single-cell RNA sequencing on multi-sector glioma biopsies to analyze tumor heterogeneity, revealing spatial patterns of invasion, progression branches, and cell-cell communication.

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.

The paper identifies HSC-primed hemogenic endothelial cells in mouse embryos using single-cell transcriptomics and functional validation, revealing their developmental trajectory and bi-potential.

This study shows that BMP signaling from somatic cells induces meiosis in male germ cells by increasing Dazl expression during embryonic development.

The paper uses single-cell RNA-seq to identify a reversible epithelial-mesenchymal transition in p63 mutation-induced differentiation defects of human iPSCs.

This study identifies Hand2as as a key lncRNA regulating HAND2 expression in heart development through single-cell RNA sequencing and knockout models, leading to congenital defects and perinatal lethality.

The paper shows that a TALE-based repressor targeting Xist intron 1 enhances iPSC generation and SCNT embryo development in mice, without affecting Xist expression.