Unwinding of an RNA duplex by the Orthoflavivirus NS3 helicase requires translocation beyond the displaced strand and is stimulated by the NS5 RdRp
Jamie J. Arnold, Shubeena Chib, Craig Cameron
This study investigates the RNA unwinding mechanism of orthoflavivirus NS3 helicases, finding that they require translocation beyond the displaced strand and are stimulated by NS5 RdRp.
bioRxiv · Feb 7, 2026 · PreprintBiochemistry