Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation
Ke Zhang, Shuchen Guo, Li Sun, Haitong Hou, Yoshinori Watanabe
This study shows that Sgo1 inhibits APC/C to prevent separase activation during mitosis but enhances Rec8 cohesin protection during meiosis through its D-box.
International Journal of Biological Macromolecules · Mar 1, 2026Peer-reviewedCell Biology